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KMID : 1102220170360020200
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Kidney Research and Clinical Practice
2017 Volume.36 No. 2 p.200 ~ p.204
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Rapid deterioration of preexisting renal insufficiency after autologous mesenchymal stem cell therapy
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Kim Jun-Seop
Lee Jong-Hak
Kwon Owen
Cho Jang-Hee
Choi Ji-Young
Park Sun-Hee
Kim Chan-Duck
Kim Yong-Jin
Kim Yong-Lim
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Abstract
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Administration of autologous mesenchymal stem cells (MSCs) has been shown to improve renal function and histological findings in acute kidney injury (AKI) models. However, its effects in chronic kidney disease (CKD) are unclear, particularly in the clinical setting. Here, we report our experience with a CKD patient who was treated by intravenous infusion of autologous MSCs derived from adipose tissue in an unknown clinic outside of Korea. The renal function of the patient had been stable for several years before MSC administration. One week after the autologous MSC infusion, the preexisting renal insufficiency was rapidly aggravated without any other evidence of AKI. Hemodialysis was started 3 months after MSC administration. Renal biopsy findings at dialysis showed severe interstitial fibrosis and inflammatory cell infiltration, with a few cells expressing CD34 and CD117, 2 surface markers of stem cells. This case highlights the potential nephrotoxicity of autologous MSC therapy in CKD patients.
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KEYWORD
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Autologous transplantation, Chronic kidney disease, Mesenchymal stem cells
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